Radiochemist, Toronto
POINT Biopharma, Canada

POINT Biopharma Global Inc. is a globally focused radiopharmaceutical company building a platform for the clinical development and commercialization of radioligands that fight cancer. POINT aims to transform precision oncology by combining a portfolio of targeted radioligand assets, a seasoned management team, an industry-leading pipeline, in-house manufacturing capabilities, and secured supply for medical isotopes including actinium-225 and lutetium-177. POINT’s active clinical trials include FRONTIER, a phase 1 trial for PNT2004, a pan-cancer program targeting fibroblast activation protein- (FAP-), and SPLASH, the phase 3 trial for PNT2002 for people with metastatic castration resistant prostate cancer (mCRPC) after second-line hormonal treatment.

TO BE CONSIDERED, APPLICANTS MUST BE LEGALLY ENTITLED TO WORK IN CANADA.

Location of work

This position will be located onsite downtown at UHN near University Avenue and College Street.

The Radiochemist will be a technical expert in the discovery and development of radiolabeling reactions to produce both therapeutic and imaging radiopharmaceuticals. They will work in collaboration with team members, other departments, and external partners (CMOs) to ensure the successful development of novel radioligands, enable the supply of radiolabeled compounds for preclinical experiments, and support the development of radiopharmaceutical manufacturing processes for clinical development.

Objectives

• Accelerate the development of the next-generation of radiopharmaceuticals by leading radiochemistry research and development for discovery programs
• Produce and supply radiolabeled compounds to support the preclinical evaluation of novel radioligands.
• Support the development of cGMP radiopharmaceutical manufacturing processes to enable clinical development activities.

Accountabilities

• Develop new radiolabeling methods and formulations for discovery and preclinical stage programs
• Synthesize, test, and supply radiolabeled compounds for preclinical experiments
• Provide technical support for the development of cGMP radiopharmaceutical manufacturing processes.
• Prepare and deliver presentations for internal and external team meetings.
• Author development reports, manuscripts for publication in journals, and patents.

Requirements

• PhD or MS degree in radiochemistry, organic chemistry, chemical engineering, or a related discipline.
• 5 to 10 years of relevant experience in radiochemistry, radiopharmaceutical manufacturing, organic chemistry, or process chemistry.
• Experienced in radiochemistry development. Hands-on experience with imaging radioisotopes (F-18, Ga-68, Cu-64, Zr-89, In-111) and/or therapeutic radioisotopes (Lu-177, Ac-225, Tb-161, Cu-67, Pb-212) is considered an asset.
• Experienced in quality control testing of radiopharmaceuticals. Hands-on experience with radio-HPLC, radio-ITLC and GC are considered assets.
• Knowledge of environmental health and radioprotection requirements are considered assets.
• Proven ability to work independently with strong organization and communication skills.
• Demonstrated ability to successfully prioritize projects and manage timelines in a fast-paced environment.
• Functional knowledge of GMPs and applicable FDA, EMA, Health Canada, USP, ICH and PDA guidelines.
• Position will require up to 10% of travel within North America and abroad into the EU. A valid passport and eligible to travel into these countries are required.

Benefits

• Healthcare plan (medical, dental, vision) effective day 1
• Disability
• Life insurance
• RRSP matching plan
• Paid Time Off (Vacation, Personal Days, Sick Days amp; Public Holidays)
• $500 fitness reimbursement
• $50 cell phone reimbursement per paycheck ($1,300 per year)

All applicants who are offered employment with POINT Biopharma will be subject to a background investigation. Offers of employment are contingent on the successful completion of a background investigation conducted in accordance with POINT Biopharma policy and state law.

This role works in a hospital setting and it is mandatory for all employees to complete health screens before onboarding. In the event the screen results show non-immunity, vaccines may need to be administered.

POINT Biopharma does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

We do not accept unsolicited inquiries or resumes from agencies.

Job Rewards and Benefits