Process Chemist, Precursors, Remote Canada
POINT Biopharma, Canada

POINT Biopharma Global Inc. is a globally focused radiopharmaceutical company building a platform for the clinical development and commercialization of radioligands that fight cancer. POINT aims to transform precision oncology by combining a portfolio of targeted radioligand assets, a seasoned management team, an industry-leading pipeline, in-house manufacturing capabilities, and secured supply for medical isotopes including actinium-225 and lutetium-177. POINT’s active clinical trials include FRONTIER, a phase 1 trial for PNT2004, a pan-cancer program targeting fibroblast activation protein- (FAP-), and SPLASH, the phase 3 trial for PNT2002 for people with metastatic castration resistant prostate cancer (mCRPC) after second-line hormonal treatment.

TO BE CONSIDERED, APPLICANTS MUST BE LEGALLY ENTITLED TO WORK IN CANADA.

Location of work

The position will be working remotely with the anticipation of travel for team and client meetings. Our business requirements are to work to accommodate Eastern Time Zone. To work in synergy, it is preferred that our applicants can work Eastern Time Zone to accommodate team and client meetings.

Overview

Reporting to the Senior Manager in Process Chemistry, the Process Chemist (Precursors) will have functional responsibility for leading efforts in planning, directing, and designing the synthesis, purification and characterization of POINT's bioactive small molecules and peptides from Ramp;D, clinical to commercial with partner organizations and vendors.

Objectives

• Support all of POINT's programs, from Ramp;D, clinical to commercial, to ensure radioligand precursors and standards are available as required for manufacturing and testing of POINT's various radioligands.
• Work closely with the Ramp;D, pre-clinical, clinical and regulatory teams to ensure compounds meet phase appropriate requirements.

Accountabilities

• Ensure synthesized compounds used in POINT's programs are produced to meet phase-appropriate specifications.
• Act as one of POINT's technical experts on the design and synthesis of radioligand precursors and directing POINT's vendors to ensure timely delivery of quality compounds to meet overall program goals and timelines.
• Monitor and evaluate project budget, tasks and risks; propose mitigation plans when required to ensure deadlines are met.
• Plays a critical role in developing and maintaining good relationships with partners, CMOs, vendors and suppliers.
• Provide verbal and written reports and presentations to managers in a clear and concise manner.
• Adhere to all applicable procedures, cGLP, cGMPs, company policies and any other quality or regulatory requirements.
• Embody and promote a quality culture and "right-the-first-time" approach as part of all activities.
• Work well in a fast-paced team environment.
• Perform other duties as assigned.

Requirements

• Masters with 3 years professional experience or a PhD in synthetic organic or medicinal chemistry in a GMP setting are the minimal requirements, but additional experience in a GMP setting is preferred.
• Proficient in all aspects of modern synthetic chemistry including designing and executing multi-step syntheses, crystallization, HPLC purification, and characterization of new compounds using HPLC, NMR and mass spectrometry is required.
• Ability to work effectively in a multi-disciplinary team setting is required.
• Strong oral and written communication skills required.
• Strong scientific, analytical and project management skills required.
• Experience working with metal chelators is highly desirable.

Competencies

• High attention to detail, well organized, and highly motivated
• Excellent ability to multitask and prioritize workload
• Strong oral and written communication skills, and interpersonal skills
• Excellent planning skills with the ability to work seamlessly as part of a team or independently
• Experience in an FDA regulated environment a plus
• Proficient in MS 365 (Excel, Word, PowerPoint)
• Remain calm and maintain composure in a fast-paced environment
• Operate and execute with an extreme sense of urgency

Benefits

• Healthcare plan (medical, dental, vision) effective day 1
• Disability
• Life insurance
• RRSP matching plan
• Paid Time Off (Vacation, Personal Days, Sick Days amp; Public Holidays)
• $500 fitness reimbursement
• $50 cell phone reimbursement per paycheck ($1,300 per year)
• $1,500 one-time allowance for remote based positions to set-up a home office

All applicants who are offered employment with POINT Biopharma will be subject to a background investigation. Offers of employment are contingent on the successful completion of a ba

Job Rewards and Benefits